Bergamottin and 5-Geranyloxy-7-methoxycoumarin Cooperate in the Cytotoxic Effect of <i>Citrus bergamia</i> (Bergamot) Essential Oil in Human Neuroblastoma SH-SY5Y Cell Line.

Maugeri, Alessandro; Lombardo, Giovanni Enrico; Musumeci, Laura; Russo, Caterina; Gangemi, Sebastiano; Calapai, Gioacchino; Cirmi, Santa; Navarra, Michele

Bergamottin and 5-Geranyloxy-7-methoxycoumarin Cooperate in the Cytotoxic Effect of Citrus bergamia (Bergamot) Essential Oil in Human Neuroblastoma SH-SY5Y Cell Line.

Maugeri, Alessandro; Lombardo, Giovanni Enrico; Musumeci, Laura; Russo, Caterina; Gangemi, Sebastiano; Calapai, Gioacchino; Cirmi, Santa; Navarra, Michele.

Affiliation

Maugeri A; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Lombardo GE; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Musumeci L; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Russo C; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.
Gangemi S; Fondazione "Prof. Antonio Imbesi", 98168 Messina, Italy.
Calapai G; Department of Clinical and Experimental Medicine, University of Messina, 98168 Messina, Italy.
Cirmi S; Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, 98168 Messina, Italy.
Navarra M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98168 Messina, Italy.

Toxins (Basel) ; 13(4)2021 04 10.

Article in En | MEDLINE | ID: mdl-33920139

Subject(s)

Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Cell Proliferation/drug effects; Coumarins/pharmacology; Furocoumarins/pharmacology; Neuroblastoma/drug therapy; Plant Oils/pharmacology; Apoptosis/drug effects; Cell Cycle Checkpoints/drug effects; Cell Line, Tumor; Drug Synergism; Humans; Membrane Potential, Mitochondrial/drug effects; Neuroblastoma/metabolism; Neuroblastoma/pathology; Reactive Oxygen Species/metabolism

Key words

5-geranyloxy-7-methoxycoumarin; Citrus bergamia; bergamot; bergamottin; cancer; coumarin; pharmacological combination; psoralen

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Full text: 1 Database: MEDLINE Main subject: Furocoumarins / Plant Oils / Antineoplastic Combined Chemotherapy Protocols / Coumarins / Cell Proliferation / Neuroblastoma / Antineoplastic Agents, Phytogenic Language: En Journal: Toxins (Basel) Year: 2021 Type: Article Affiliation country: Italy

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