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The Natural Products and Extracts: Anti-Triple-Negative Breast Cancer in Vitro.
Chen, Han; Yang, Jiaping; Yang, Yanlong; Zhang, Jianpeng; Xu, Yao; Lu, Xiaoling.
Affiliation
  • Chen H; College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Yang J; College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Yang Y; School of Traditional Chinese Medicine, Naval Medical University, 200433, Shanghai, P. R. China.
  • Zhang J; College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Xu Y; College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
  • Lu X; College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Xiangyin Road 800, Shanghai, 200433, P. R. China.
Chem Biodivers ; 18(7): e2001047, 2021 Jul.
Article in En | MEDLINE | ID: mdl-34000082
ABSTRACT
Triple-negative breast cancer (TNBC) makes up 15 % to 20 % of all breast cancer (BC) cases, and represents one of the most challenging malignancies to treat. For many years, chemotherapy has been the main treatment option for TNBC. Natural products isolated from marine organisms and terrestrial organisms with great structural diversity and high biochemical specificity form a compound library for the assessment and discovery of new drugs. In this review, we mainly focused on natural compounds and extracts (from marine and terrestrial environments) with strong anti-TNBC activities (IC50 <100 µM) and their possible mechanisms reported in the past six years (2015-2021).
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Full text: 1 Database: MEDLINE Main subject: Biological Products / Plant Extracts / Triple Negative Breast Neoplasms / Antineoplastic Agents, Phytogenic Language: En Journal: Chem Biodivers Year: 2021 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Biological Products / Plant Extracts / Triple Negative Breast Neoplasms / Antineoplastic Agents, Phytogenic Language: En Journal: Chem Biodivers Year: 2021 Type: Article