Tozinameran (BNT162b2) Vaccine: The Journey from Preclinical Research to Clinical Trials and Authorization.

Khehra, Nimrat; Padda, Inderbir; Jaferi, Urooj; Atwal, Harshan; Narain, Shreya; Parmar, Mayur S

Khehra, Nimrat; Padda, Inderbir; Jaferi, Urooj; Atwal, Harshan; Narain, Shreya; Parmar, Mayur S.

Affiliation

Khehra N; Saint James School of Medicine, Arnos Vale, Saint Vincent and the Grenadines.
Padda I; University of Washington, Seattle, WA, USA.
Jaferi U; All Saints University School of Medicine, Roseau, Dominica.
Atwal H; Saint James School of Medicine, Arnos Vale, Saint Vincent and the Grenadines.
Narain S; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Tampa Bay Campus, Clearwater, FL, USA.
Parmar MS; Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Tampa Bay Campus, Clearwater, FL, USA. mparmar@nova.edu.

AAPS PharmSciTech ; 22(5): 172, 2021 Jun 07.

Article in En | MEDLINE | ID: mdl-34100150

Subject(s)

COVID-19 Vaccines/administration & dosage; COVID-19/prevention & control; Clinical Trials as Topic/methods; Drug Approval/methods; SARS-CoV-2/drug effects; Animals; Antibodies, Neutralizing/drug effects; Antibodies, Neutralizing/metabolism; BNT162 Vaccine; COVID-19/epidemiology; COVID-19/metabolism; COVID-19 Vaccines/adverse effects; COVID-19 Vaccines/metabolism; Clinical Trials as Topic/legislation & jurisprudence; Drug Approval/legislation & jurisprudence; Drug Evaluation, Preclinical/methods; Exanthema/chemically induced; Female; Humans; Male; SARS-CoV-2/metabolism; Spike Glycoprotein, Coronavirus/drug effects; Spike Glycoprotein, Coronavirus/metabolism; Vaccination/legislation & jurisprudence; Vaccination/methods

Key words

BNT162b1; BNT162b2; BioNTech; COVID-19; Pfizer; SARS-CoV-2; adolescents; adverse effects; antibody response; children; clinical trials; efficacy; phase 1 trials; phase 1/2 trials; phase 2 trials; phase 2/ 3 trials; phase 3 trials; preclinical trials; pregnant women; real-world outcomes; safety; tozinameran; vaccine

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Full text: 1 Database: MEDLINE Main subject: Clinical Trials as Topic / Drug Approval / COVID-19 Vaccines / SARS-CoV-2 / COVID-19 Type of study: Clinical_trials / Prognostic_studies Language: En Journal: AAPS PharmSciTech Year: 2021 Type: Article Affiliation country: Saint Vincent and the Grenadines

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