Your browser doesn't support javascript.
loading
Monoterpene indole alkaloids from the roots of Bousigonia mekongensis and their anti-diabetic nephropathy activity.
Wang, Zhi-Wei; Wang, Ya-Lan; Zhang, Jin-Ping; Wei, Quan-Hao; Wang, Xiao-Jing.
Affiliation
  • Wang ZW; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China; Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China. Electronic address: wzwcpu@1
  • Wang YL; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China; Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250000, China; Shandong Analysis and Test Center, Qilu U
  • Zhang JP; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China; Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250000, China; Shandong Analysis and Test Center, Qilu U
  • Wei QH; School of Pharmaceutical Sciences, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China; Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250000, China; Shandong Analysis and Test Center, Qilu U
  • Wang XJ; Institute of Materia Medica, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan 250000, China. Electronic address: xj68cn@163.com.
Fitoterapia ; 153: 104964, 2021 Sep.
Article in En | MEDLINE | ID: mdl-34146637
ABSTRACT
Four new monoterpene indole alkaloids (1-4) together with six known alkaloids (5-10) were isolated from the roots of Bousigonia mekongensis. Compounds 3 and 4 were the first examples of condylocarpan-adenine type alkaloids obtained from natural plant resource. Their structures were elucidated on the basis of spectroscopic data. All compounds were evaluated for their inhibiting glucose-induced mesanginal cell proliferation and protecting high glucose-evoked podocyte injury activities. (-)-demethoxycarbonyldihydrogambirtannine (5) can significantly antagonize glucose-induced podocyte injury with EC50 value of 6.5 ± 1.2 µM.
Subject(s)
Key words
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Apocynaceae / Indole Alkaloids / Monoterpenes Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2021 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Apocynaceae / Indole Alkaloids / Monoterpenes Country/Region as subject: Asia Language: En Journal: Fitoterapia Year: 2021 Type: Article