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Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease.
Milligan, Jennifer C; Zeisner, Theresa U; Papageorgiou, George; Joshi, Dhira; Soudy, Christelle; Ulferts, Rachel; Wu, Mary; Lim, Chew Theng; Tan, Kang Wei; Weissmann, Florian; Canal, Berta; Fujisawa, Ryo; Deegan, Tom; Nagaraj, Hema; Bineva-Todd, Ganka; Basier, Clovis; Curran, Joseph F; Howell, Michael; Beale, Rupert; Labib, Karim; O'Reilly, Nicola; Diffley, John F X.
Affiliation
  • Milligan JC; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Zeisner TU; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Papageorgiou G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Joshi D; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Soudy C; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Ulferts R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Wu M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Lim CT; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Tan KW; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Weissmann F; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Canal B; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Fujisawa R; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Deegan T; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • Nagaraj H; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Bineva-Todd G; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Basier C; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Curran JF; Cell Cycle Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Howell M; High Throughput Screening STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Beale R; Cell Biology of Infection Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Labib K; The MRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.
  • O'Reilly N; Peptide Chemistry STP, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
  • Diffley JFX; Chromosome Replication Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, U.K.
Biochem J ; 478(13): 2499-2515, 2021 07 16.
Article in En | MEDLINE | ID: mdl-34198327
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Drug Evaluation, Preclinical / Small Molecule Libraries / Coronavirus 3C Proteases / SARS-CoV-2 Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Biochem J Year: 2021 Type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Drug Evaluation, Preclinical / Small Molecule Libraries / Coronavirus 3C Proteases / SARS-CoV-2 Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Biochem J Year: 2021 Type: Article Affiliation country: United kingdom