Four new dammarane triterpenoid glycosides from the leaves of Cyclocarya paliurus and their SIRT1 activation activities.
Fitoterapia
; 154: 105003, 2021 Oct.
Article
in En
| MEDLINE
| ID: mdl-34333032
ABSTRACT
Four new C-11 monosaccharide attached dammarane triterpenoid glycosides cypaliurusides SV (1-4), along with nine known dammarane triterpenoid glycosides (5-13) were isolated from a CHCl3-soluble extract of the leaves of Cyclocarya paliurus. All characterized compounds were assayed for their cytotoxicities against HepG2 cells and 10 compounds were evaluated for the agonistic effects on sirtuin1 (SIRT1). The results showed that compounds 1, 5 and 6 were strongly cytotoxic in HepG2 cell line. Two dammarane triterpenoid glycosides 3 and 10 exhibited agonistic activities on SIRT1 with IC50 of 10 µM and 20 µM, respectively.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Triterpenes
/
Juglandaceae
/
Sirtuin 1
/
Glycosides
Country/Region as subject:
Asia
Language:
En
Journal:
Fitoterapia
Year:
2021
Type:
Article