Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1&#945;, NF-&#954;B, and VEGF pathways.

Viswanatha, Gollapalle Lakshminarayanashastry; Shylaja, Hanumanthappa; Nandakumar, Krishnadas; Rajesh, Subbanna; Male, C H K V L S N Anjana

Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways.

Viswanatha, Gollapalle Lakshminarayanashastry; Shylaja, Hanumanthappa; Nandakumar, Krishnadas; Rajesh, Subbanna; Male, C H K V L S N Anjana.

Affiliation

Viswanatha GL; Independent Researcher, No. 387/511/A, Megalabeedi, Kengeri, Bangalore, 560060, India. glv_000@yahoo.com.
Shylaja H; Independent Researcher, Kengeri, Bangalore, 560060, India.
Nandakumar K; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, 576104, India.
Rajesh S; Department of Pharmacology, Government College of Pharmacy, Bangalore, 560027, India.
Male CHKVLSNA; Department of Pharmaceutical Chemistry and Phytochemistry, Nirmala College of Pharmacy, Mangalagiri, 522503, India.

Inflammopharmacology ; 29(5): 1565-1577, 2021 Oct.

Article in En | MEDLINE | ID: mdl-34365555

Subject(s)

Glucosides/pharmacology; Lamiaceae/chemistry; Phenols/pharmacology; Plant Extracts/pharmacology; Stroke/prevention & control; Animals; Antioxidants/administration & dosage; Antioxidants/isolation & purification; Antioxidants/pharmacology; Disease Models, Animal; Dose-Response Relationship, Drug; Glucosides/administration & dosage; Glucosides/isolation & purification; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Male; NF-kappa B/metabolism; Phenols/administration & dosage; Phenols/isolation & purification; Plant Extracts/administration & dosage; Plant Extracts/chemistry; Rats; Rats, Wistar; Reperfusion Injury/drug therapy; Reperfusion Injury/physiopathology; Vascular Endothelial Growth Factor A/metabolism

Key words

Acteoside; Colebrookea oppositifolia; Hypoxia-inducible factor 1-alpha (HIF-1α); Ischemic stroke; Nuclear factor-kappa-B (NF-κB); Vascular endothelia growth factor (VEGF)

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Full text: 1 Database: MEDLINE Main subject: Phenols / Plant Extracts / Lamiaceae / Stroke / Glucosides Type of study: Prognostic_studies Language: En Journal: Inflammopharmacology Year: 2021 Type: Article Affiliation country: India

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