High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming.

Liu, Qing; Zhang, Linqing; Zhu, Min-Sheng; Wan, Guoqiang

Liu, Qing; Zhang, Linqing; Zhu, Min-Sheng; Wan, Guoqiang.

Affiliation

Liu Q; MOE Key Laboratory of Model Animal for Disease Study, Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing 210032, China.
Zhang L; MOE Key Laboratory of Model Animal for Disease Study, Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing 210032, China.
Zhu MS; MOE Key Laboratory of Model Animal for Disease Study, Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing 210032, China.
Wan G; MOE Key Laboratory of Model Animal for Disease Study, Department of Otorhinolaryngology-Head and Neck Surgery, The Affiliated Drum Tower Hospital of Medical School, Model Animal Research Center of Medical School, Nanjing University, Nanjing 210032, China; Research Institute of Otolaryngology, No. 32

Stem Cell Reports ; 16(9): 2257-2273, 2021 09 14.

Article in En | MEDLINE | ID: mdl-34525385

Subject(s)

Cellular Reprogramming; Cochlea/metabolism; High-Throughput Screening Assays; Mitogen-Activated Protein Kinase Kinases/metabolism; Organoids/metabolism; Receptors, Vascular Endothelial Growth Factor/metabolism; Transforming Growth Factor beta1/metabolism; Animals; Cell Culture Techniques, Three Dimensional/methods; Cell Differentiation/drug effects; Cell Differentiation/genetics; Cells, Cultured; Cellular Reprogramming/genetics; Cochlea/cytology; Drug Discovery/methods; Drug Evaluation, Preclinical; Gene Expression Regulation/drug effects; Hair Cells, Auditory/cytology; Hair Cells, Auditory/drug effects; Hair Cells, Auditory/metabolism; Mice; Mice, Transgenic; Organoids/cytology; Phenylurea Compounds/pharmacology; Pyridines/pharmacology; Receptors, G-Protein-Coupled/genetics; Receptors, G-Protein-Coupled/metabolism; Signal Transduction/drug effects

Key words

Regorafenib; drug screening; hair cells; inner ear; organoids; reprogramming

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Full text: 1 Database: MEDLINE Main subject: Organoids / Cochlea / Mitogen-Activated Protein Kinase Kinases / Receptors, Vascular Endothelial Growth Factor / Transforming Growth Factor beta1 / Cellular Reprogramming / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Stem Cell Reports Year: 2021 Type: Article Affiliation country: China

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