Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-&#954;B signaling pathway.

Yuan, Li; Zhang, Lingming; Yao, Na; Wu, Lingna; Liu, Jianming; Liu, Fanglan; Zhang, Hong; Hu, Xiao; Xiong, Yuqing; Xia, Chunhua

Upregulation of UGT1A1 expression by ursolic acid and oleanolic acid via the inhibition of the PKC/NF-κB signaling pathway.

Yuan, Li; Zhang, Lingming; Yao, Na; Wu, Lingna; Liu, Jianming; Liu, Fanglan; Zhang, Hong; Hu, Xiao; Xiong, Yuqing; Xia, Chunhua.

Affiliation

Yuan L; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Zhang L; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Yao N; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Wu L; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Liu J; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Liu F; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Zhang H; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Hu X; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Xiong Y; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China.
Xia C; Clinical Pharmacology Institute, Nanchang University, Nanchang 330006, PR China. Electronic address: xch720917@ncu.edu.cn.

Phytomedicine ; 92: 153726, 2021 Nov.

Article in En | MEDLINE | ID: mdl-34536821

Subject(s)

Oleanolic Acid; Glucuronosyltransferase; NF-kappa B/metabolism; Oleanolic Acid/pharmacology; Protein Kinase C/metabolism; Signal Transduction; Triterpenes; Up-Regulation; Ursolic Acid

Key words

Nuclear factor-κB (NF-κB); Oleanolic acid (OA); Protein kinase C (PKC); UDP-glucuronosyltransferase 1A1 (UGT1A1); Ursolic acid (UA)

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