Screening Platforms for Genetic Epilepsies-Zebrafish, iPSC-Derived Neurons, and Organoids.

Shcheglovitov, Aleksandr; Peterson, Randall T

Shcheglovitov, Aleksandr; Peterson, Randall T.

Affiliation

Shcheglovitov A; Department of Neurobiology, University of Utah, Salt Lake City, UT, 84112, USA. alexsh@neuro.utah.edu.
Peterson RT; College of Pharmacy, University of Utah, Salt Lake City, UT, USA. randall.peterson@pharm.utah.edu.

Neurotherapeutics ; 18(3): 1478-1489, 2021 07.

Article in En | MEDLINE | ID: mdl-34595731

Subject(s)

Anticonvulsants/therapeutic use; Disease Models, Animal; Drug Evaluation, Preclinical/methods; Epilepsy/genetics; Induced Pluripotent Stem Cells/physiology; Organoids/physiology; Animals; Anticonvulsants/pharmacology; Epilepsy/diagnosis; Epilepsy/drug therapy; Humans; Induced Pluripotent Stem Cells/drug effects; Neurons/drug effects; Neurons/physiology; Organoids/drug effects; Zebrafish

Key words

Developmental and epileptic encephalopathy (DEE); Drug discovery; Epilepsy; Organoids; Stem cells; Zebrafish; iPSC

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Full text: 1 Database: MEDLINE Main subject: Organoids / Disease Models, Animal / Drug Evaluation, Preclinical / Epilepsy / Induced Pluripotent Stem Cells / Anticonvulsants Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Language: En Journal: Neurotherapeutics Year: 2021 Type: Article Affiliation country: United States

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