Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARÎ³, NF-&#954;B, and PI3K/Akt Signaling Pathways.

Yassin, Nour Y S; AbouZid, Sameh F; El-Kalaawy, Asmaa M; Ali, Tarek M; Elesawy, Basem H; Ahmed, Osama M

Tackling of Renal Carcinogenesis in Wistar Rats by Silybum marianum Total Extract, Silymarin, and Silibinin via Modulation of Oxidative Stress, Apoptosis, Nrf2, PPARÎ³, NF-κB, and PI3K/Akt Signaling Pathways.

Yassin, Nour Y S; AbouZid, Sameh F; El-Kalaawy, Asmaa M; Ali, Tarek M; Elesawy, Basem H; Ahmed, Osama M.

Affiliation

Yassin NYS; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.
AbouZid SF; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
El-Kalaawy AM; Department of Pharmacology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Ali TM; Department of Physiology, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Elesawy BH; Department of Pathology, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Ahmed OM; Physiology Division, Zoology Department, Faculty of Science, Beni-Suef University, P.O. Box 62521, Beni-Suef, Egypt.

Oxid Med Cell Longev ; 2021: 7665169, 2021.

Article in En | MEDLINE | ID: mdl-34630852

Subject(s)

Antineoplastic Agents, Phytogenic/administration & dosage; Apoptosis/drug effects; Carcinogenesis/drug effects; Carcinogenesis/metabolism; Kidney Neoplasms/drug therapy; Kidney Neoplasms/metabolism; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Oxidative Stress/drug effects; PPAR gamma/metabolism; Phosphatidylinositol 3-Kinases/metabolism; Phytotherapy/methods; Plant Extracts/administration & dosage; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction/drug effects; Silybin/administration & dosage; Silybum marianum/chemistry; Silymarin/administration & dosage; Animals; Carcinogenesis/chemically induced; Disease Models, Animal; Kidney Neoplasms/chemically induced; Kidney Neoplasms/prevention & control; Male; Rats; Rats, Wistar

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Plantas_medicinales Main subject: Silymarin / Plant Extracts / Signal Transduction / NF-kappa B / Apoptosis / Oxidative Stress / Phosphatidylinositol 3-Kinases / Silybum marianum / PPAR gamma / Proto-Oncogene Proteins c-akt Type of study: Prognostic_studies Language: En Journal: Oxid Med Cell Longev Year: 2021 Type: Article Affiliation country: Egypt

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google