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Valproic acid disables the Nrf2 anti-oxidant response in acute myeloid leukaemia cells enhancing reactive oxygen species-mediated killing.
Jiang, Yao; Southam, Andrew D; Trova, Sandro; Beke, Flavio; Alhazmi, Bader; Francis, Thomas; Radotra, Anshul; di Maio, Alessandro; Drayson, Mark T; Bunce, Chris M; Khanim, Farhat L.
Affiliation
  • Jiang Y; School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
  • Southam AD; School of Biosciences, University of Birmingham, Birmingham, UK.
  • Trova S; School of Biosciences, University of Birmingham, Birmingham, UK.
  • Beke F; CRUK Cancer Institute, University of Cambridge, Cambridge, UK.
  • Alhazmi B; School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
  • Francis T; Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, King's College London, London, UK.
  • Radotra A; University Hospitals Coventry and Warwickshire, Clifford Bridge Rd, Coventry, UK.
  • di Maio A; School of Biosciences, University of Birmingham, Birmingham, UK.
  • Drayson MT; Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
  • Bunce CM; School of Biosciences, University of Birmingham, Birmingham, UK.
  • Khanim FL; School of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham, UK. F.L.Khanim@bham.ac.uk.
Br J Cancer ; 126(2): 275-286, 2022 02.
Article in En | MEDLINE | ID: mdl-34686779
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Full text: 1 Database: MEDLINE Main subject: Bezafibrate / Leukemia, Myeloid, Acute / Valproic Acid / Reactive Oxygen Species / Medroxyprogesterone Acetate / NF-E2-Related Factor 2 / Antioxidants Type of study: Prognostic_studies Language: En Journal: Br J Cancer Year: 2022 Type: Article Affiliation country: United kingdom
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Full text: 1 Database: MEDLINE Main subject: Bezafibrate / Leukemia, Myeloid, Acute / Valproic Acid / Reactive Oxygen Species / Medroxyprogesterone Acetate / NF-E2-Related Factor 2 / Antioxidants Type of study: Prognostic_studies Language: En Journal: Br J Cancer Year: 2022 Type: Article Affiliation country: United kingdom