The modulation of SIRT1 and SIRT3 by natural compounds as a therapeutic target in doxorubicin-induced cardiotoxicity: A review.

Tabrizi, Fatemeh B; Yarmohammadi, Fatemeh; Hayes, A Wallace; Karimi, Gholamreza

Tabrizi, Fatemeh B; Yarmohammadi, Fatemeh; Hayes, A Wallace; Karimi, Gholamreza.

Affiliation

Tabrizi FB; Department of Medicinal Chemistry, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Yarmohammadi F; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Hayes AW; Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Karimi G; Center for Environmental Occupational Risk Analysis and Management, College of Public Health, University of South Florida, Tampa, Florida, USA.

J Biochem Mol Toxicol ; 36(1): e22946, 2022 Jan.

Article in En | MEDLINE | ID: mdl-34747550

Subject(s)

Berberine/therapeutic use; Dioxoles/therapeutic use; Doxorubicin/adverse effects; Heart Diseases/enzymology; Lignans/therapeutic use; Myocardium/enzymology; Sirtuin 1/metabolism; Sirtuin 3/metabolism; Animals; Cardiotoxicity/drug therapy; Cardiotoxicity/enzymology; Doxorubicin/pharmacology; Heart Diseases/chemically induced; Heart Diseases/drug therapy; Humans

Key words

SIRT1; SIRT3; apoptosis; cardiac injury; inflammation; oxidative stress

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Berberine / Doxorubicin / Lignans / Dioxoles / Sirtuin 1 / Sirtuin 3 / Heart Diseases / Myocardium Language: En Journal: J Biochem Mol Toxicol Year: 2022 Type: Article Affiliation country: Iran

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