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Cancer Influences the Elemental Composition of the Myocardium More Strongly than Conjugated Linoleic Acids-Chemometric Approach to Cardio-Oncological Studies.
Bialek, Agnieszka; Bialek, Malgorzata; Lepionka, Tomasz; Ruszczynska, Anna; Bulska, Ewa; Czauderna, Marian.
Affiliation
  • Bialek A; Department of Biotechnology and Nutrigenomics, Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Postepu 36A Jastrzebiec, 05-552 Magdalenka, Poland.
  • Bialek M; Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jablonna, Poland.
  • Lepionka T; Department of Bioaerosols, The Biological Threats Identification and Countermeasure Center of the General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Lubelska 4 St, 24-100 Pulawy, Poland.
  • Ruszczynska A; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Bulska E; Biological and Chemical Research Centre, Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02-089 Warsaw, Poland.
  • Czauderna M; Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jablonna, Poland.
Molecules ; 26(23)2021 Nov 25.
Article in En | MEDLINE | ID: mdl-34885709
The aim of the study was to verify in a cardio-oncological model experiment if conjugated linoleic acids (CLA) fed to rats with mammary tumors affect the content of selected macro- and microelements in their myocardium. The diet of Sprague-Dawley females was supplemented either with CLA isomers or with safflower oil. In hearts of rats suffering from breast cancer, selected elements were analyzed with a quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS). In order to better understand the data trends, cluster analysis, principal component analysis and linear discriminant analysis were applied. Mammary tumors influenced macro- and microelements content in the myocardium to a greater extent than applied diet supplementation. Significant influences of diet (p = 0.0192), mammary tumors (p = 0.0200) and interactions of both factors (p = 0.0151) were documented in terms of Fe content. CLA significantly decreased the contents of Cu and Mn (p = 0.0158 and p = 0.0265, respectively). The level of Ni was significantly higher (p = 0.0073), which was more pronounced in groups supplemented with CLA. The obtained results confirmed antioxidant properties of CLA and the relationship with Se deposition. Chemometric techniques distinctly showed that the coexisting pathological process induced differences to the greater extent than diet supplementation in the elemental content in the myocardium, which may impinge on cardiac tissue's susceptibility to injuries.
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Full text: 1 Database: MEDLINE Main subject: Mammary Neoplasms, Animal / Linoleic Acids, Conjugated / Myocardium / Antioxidants Type of study: Prognostic_studies Language: En Journal: Molecules Year: 2021 Type: Article Affiliation country: Poland

Full text: 1 Database: MEDLINE Main subject: Mammary Neoplasms, Animal / Linoleic Acids, Conjugated / Myocardium / Antioxidants Type of study: Prognostic_studies Language: En Journal: Molecules Year: 2021 Type: Article Affiliation country: Poland