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Technology insight: Plant-derived vesicles-How far from the clinical biotherapeutics and therapeutic drug carriers?
Cong, Minghui; Tan, Shenyu; Li, Simin; Gao, Lina; Huang, Luqi; Zhang, Huang-Ge; Qiao, Hongzhi.
Affiliation
  • Cong M; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Tan S; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Li S; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Gao L; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
  • Huang L; State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Electronic address: huangluqi01@126.com.
  • Zhang HG; Robley Rex Veterans Affairs Medical Center, Louisville, KY 40206, USA; James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, KY 40202, USA. Electronic address: h0zhan17@louisville.edu.
  • Qiao H; Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Jiangsu Engineering Research Center for Efficient Delivery System of TCM, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China; State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Cent
Adv Drug Deliv Rev ; 182: 114108, 2022 03.
Article in En | MEDLINE | ID: mdl-34990792
ABSTRACT
Within the past decades, extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. Besides EVs, exosome-like nanoparticles (ELNs) derived from plants were also emerging. Comparing to EVs, ELNs are source-widespread, cost-effective and easy to obtain. Their definite activities can be utilized for potential prevention/treatment of an abundance of diseases, including metabolic syndrome, cancer, colitis, alcoholic hepatitis and infectious diseases, which highlights ELNs as promising biotherapeutics. In addition, the potential of ELNs as natural or engineered drug carriers is also attractive. In this review, we tease out the timeline of plant EVs and ELNs, introduce the arising separation, purification and characterization techniques, state the stability and transport manner, discuss the therapeutic opportunities as well as the potential as novel drug carriers. Finally, the challenges and the direction of efforts to realize the clinical transformation of ELNs are also discussed.
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Full text: 1 Database: MEDLINE Main subject: Plants / Drug Carriers / Chemistry, Pharmaceutical / Exosomes / Extracellular Vesicles Language: En Journal: Adv Drug Deliv Rev Year: 2022 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Plants / Drug Carriers / Chemistry, Pharmaceutical / Exosomes / Extracellular Vesicles Language: En Journal: Adv Drug Deliv Rev Year: 2022 Type: Article Affiliation country: China