Panax notoginseng saponins reverse P-gp-mediated steroid resistance in lupus: involvement in the suppression of the SIRT1/FoxO1/MDR1 signalling pathway in lymphocytes.

Pan, Feng; Li, Yue-Jin; Lu, Ying

Pan, Feng; Li, Yue-Jin; Lu, Ying.

Affiliation

Pan F; Department of Immunology and Inflammation, The Second Clinical Medical College of Zhejiang Chinese Medical University, Hangzhou, 310014, Zhejiang, China.
Li YJ; Department of Immunology and Inflammation, Shanxi Hospital of Integrated Traditional and Western Medicine, Taiyuan, 030000, Shanxi, China.
Lu Y; Department of Immunology and Inflammation, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, 310007, Zhejiang, China. hz_luying@126.com.

BMC Complement Med Ther ; 22(1): 13, 2022 Jan 12.

Article in En | MEDLINE | ID: mdl-35022006

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors; Lupus Nephritis/drug therapy; Panax notoginseng; Saponins/therapeutic use; Steroids/pharmacology; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Animals; Drug Resistance; Female; Forkhead Box Protein O1/metabolism; Lupus Nephritis/immunology; Lupus Nephritis/metabolism; Lymphocytes/drug effects; Lymphocytes/metabolism; Mice; Signal Transduction/drug effects; Sirtuin 1/metabolism; Th17 Cells

Key words

Lupus nephritis; P-glycoprotein; Panax notoginseng saponins; SIRT1/FoxO1/MDR1 signalling pathway; Steroid resistance; Th17 cells

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Saponins / Steroids / Lupus Nephritis / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Panax notoginseng Language: En Journal: BMC Complement Med Ther Year: 2022 Type: Article Affiliation country: China

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