Citric Acid-Enriched Extract of Ripe <i>Prunus mume</i> (Siebold) Siebold & Zucc. Induces Laxative Effects by Regulating the Expression of Aquaporin 3 and Prostaglandin E<sub>2</sub> in Rats with Loperamide-Induced Constipation.

Na, Ju-Ryun; Kim, Eun; Na, Chang-Su; Kim, Sunoh

Citric Acid-Enriched Extract of Ripe Prunus mume (Siebold) Siebold & Zucc. Induces Laxative Effects by Regulating the Expression of Aquaporin 3 and Prostaglandin E₂ in Rats with Loperamide-Induced Constipation.

Na, Ju-Ryun; Kim, Eun; Na, Chang-Su; Kim, Sunoh.

Affiliation

Na JR; Central R&D Center, B&Tech Co., Ltd., Gwangju, Korea.
Kim E; Central R&D Center, B&Tech Co., Ltd., Gwangju, Korea.
Na CS; College of Korean Medicine, Dongshin University, Naju-si, Korea.
Kim S; Central R&D Center, B&Tech Co., Ltd., Gwangju, Korea.

J Med Food ; 25(1): 12-23, 2022 Jan.

Article in En | MEDLINE | ID: mdl-35029511

Subject(s)

Laxatives; Prunus; Animals; Aquaporin 3; Citric Acid/therapeutic use; Constipation/chemically induced; Constipation/drug therapy; Loperamide; Prostaglandins/therapeutic use; Prostaglandins E/therapeutic use; Rats

Key words

Prunus mume (Siebold) Siebold & Zucc; aquaporin 3 (AQP3); constipation; laxative effect; loperamide; prostaglandin E2 (PGE2)

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