Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain.

Boinon, Lisa; Yu, Jie; Madura, Cynthia L; Chefdeville, Aude; Feinstein, Douglas L; Moutal, Aubin; Khanna, Rajesh

Boinon, Lisa; Yu, Jie; Madura, Cynthia L; Chefdeville, Aude; Feinstein, Douglas L; Moutal, Aubin; Khanna, Rajesh.

Affiliation

Boinon L; Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States . Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang
Yu J; Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States . Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang
Madura CL; Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States . Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang
Chefdeville A; Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States . Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang
Feinstein DL; Department of Anesthesiology, University of Illinois, Chicago, Chicago, IL, United States.
Moutal A; Jesse Brown VA Medical Center, Chicago, IL, United States.
Khanna R; Department of Pharmacology, College of Medicine, the University of Arizona, Tucson, AZ, United States . Dr. Yu is now with the Institute of Chinese Medicine Clinical Basics, Institute of Chinese Medicine on Rheumatology, College of Basic Medical Science, Zhejiang Chinese Medical University, Binjiang

Pain ; 163(2): e368-e381, 2022 02 01.

Article in En | MEDLINE | ID: mdl-35029600

Subject(s)

Astrocytes; Neuralgia; Animals; Female; Male; Mice; Neuralgia/genetics; Neuralgia/metabolism; Neurons/metabolism; Nociception; Rats; Synaptic Transmission

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