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Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.
Schultz, David C; Johnson, Robert M; Ayyanathan, Kasirajan; Miller, Jesse; Whig, Kanupriya; Kamalia, Brinda; Dittmar, Mark; Weston, Stuart; Hammond, Holly L; Dillen, Carly; Ardanuy, Jeremy; Taylor, Louis; Lee, Jae Seung; Li, Minghua; Lee, Emily; Shoffler, Clarissa; Petucci, Christopher; Constant, Samuel; Ferrer, Marc; Thaiss, Christoph A; Frieman, Matthew B; Cherry, Sara.
Affiliation
  • Schultz DC; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. dschultz@pennmedicine.upenn.edu.
  • Johnson RM; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ayyanathan K; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Miller J; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Whig K; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
  • Kamalia B; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA.
  • Dittmar M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Weston S; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Hammond HL; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Dillen C; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Ardanuy J; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Taylor L; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA.
  • Lee JS; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Li M; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Lee E; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Shoffler C; Metabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
  • Petucci C; Metabolomics Core, Penn Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA.
  • Constant S; Epithelix, Geneva, Switzerland.
  • Ferrer M; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Thaiss CA; Department of Microbiology, University of Pennsylvania, Philadelphia, PA, USA.
  • Frieman MB; Department of Microbiology and Immunology, Center for Pathogen Research, University of Maryland School of Medicine, Baltimore, MD, USA. mfrieman@som.umaryland.edu.
  • Cherry S; Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA, USA. cherrys@pennmedicine.upenn.edu.
Nature ; 604(7904): 134-140, 2022 04.
Article in En | MEDLINE | ID: mdl-35130559
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Pyrimidines / Drug Evaluation, Preclinical / SARS-CoV-2 / Nucleosides Type of study: Guideline Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States
Fulltext
Add to My VHL
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Full text: 1 Database: MEDLINE Main subject: Antiviral Agents / Pyrimidines / Drug Evaluation, Preclinical / SARS-CoV-2 / Nucleosides Type of study: Guideline Language: En Journal: Nature Year: 2022 Type: Article Affiliation country: United States