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Three New Aglain Derivatives from Aglaia odorata Lour. and Their Cytotoxic Activities.
Wu, Pan-Feng; Liu, Juan; Li, Ya-Nan; Ding, Ru; Tan, Rong; Yang, Xiao-Meng; Yu, Yan; Hao, Xiao-Jiang; Yuan, Chun-Mao; Yi, Ping.
Affiliation
  • Wu PF; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, P. R. China.
  • Liu J; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, P. R. China.
  • Li YN; Graduate School, Guizhou Medical University, University Town, Guian New District, Guiyang, 550025, P. R. China.
  • Ding R; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, P. R. China.
  • Tan R; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, P. R. China.
  • Yang XM; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, P. R. China.
  • Yu Y; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, P. R. China.
  • Hao XJ; Pharmacy Affiliated Hospital of Guizhou Medical University, Guiyang, 550001, P. R. China.
  • Yuan CM; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, P. R. China.
  • Yi P; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550014, P. R. China.
Chem Biodivers ; 19(4): e202101008, 2022 Apr.
Article in En | MEDLINE | ID: mdl-35194923
ABSTRACT
Three new aglain derivatives (1-3), one known aglain derivative (4), two known rocaglamide derivatives (5 and 6), four known triterpenoids (7-10), and three steroids (11-13) were isolated from Aglaia odorata Lour. Their structures were established through the analysis of detailed spectroscopic data and electronic circular dichroism calculations. Five compounds (1 and 4-7) exhibited cytotoxic activities on human leukemia cells (HEL) and human breast cancer cells with IC50 values in the range of 0.03-8.40 µM. In particular, the cytotoxicity of compound 5 was six times stronger than that of the positive control (adriamycin) in HEL cell lines.
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Full text: 1 Database: MEDLINE Main subject: Triterpenes / Aglaia / Antineoplastic Agents / Antineoplastic Agents, Phytogenic Language: En Journal: Chem Biodivers Year: 2022 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Triterpenes / Aglaia / Antineoplastic Agents / Antineoplastic Agents, Phytogenic Language: En Journal: Chem Biodivers Year: 2022 Type: Article