Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.
Proc Natl Acad Sci U S A
; 119(22): e2201355119, 2022 05 31.
Article
in En
| MEDLINE
| ID: mdl-35613048
Area-specific axonal projections from the mammalian thalamus shape unique cellular organization in target areas in the adult neocortex. How these axons control neurogenesis and early neuronal fate specification is poorly understood. By using mutant mice lacking the majority of thalamocortical axons, we show that these axons are required for the production and specification of the proper number of layer 4 neurons in primary sensory areas by the neonatal stage. Part of these area-specific roles is played by the thalamus-derived molecule, VGF. Our work reveals that extrinsic cues from sensory thalamic projections have an early role in the formation of cortical cytoarchitecture by enhancing the production and specification of layer 4 neurons.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Axons
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Thalamus
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Cerebral Cortex
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Body Patterning
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Neurogenesis
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2022
Type:
Article