Hyperthermia increases HSP production in human PDMCs by stimulating ROS formation, p38 MAPK and Akt signaling, and increasing HSF1 activity.

Liu, Ju-Fang; Chen, Po-Chun; Ling, Thai-Yen; Hou, Chun-Han

Liu, Ju-Fang; Chen, Po-Chun; Ling, Thai-Yen; Hou, Chun-Han.

Affiliation

Liu JF; School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, 110, Taiwan.
Chen PC; Department of Medical Research, China Medical University Hospital, China Medical University, Taichung, 404, Taiwan.
Ling TY; Department of Life Science, National Taiwan Normal University, Taipei, 116, Taiwan.
Hou CH; Translational Medicine Center, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, 111, Taiwan.

Stem Cell Res Ther ; 13(1): 236, 2022 06 03.

Article in En | MEDLINE | ID: mdl-35659731

Subject(s)

Hyperthermia, Induced; p38 Mitogen-Activated Protein Kinases; Animals; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; HSP70 Heat-Shock Proteins/metabolism; Heat Shock Transcription Factors/genetics; Heat Shock Transcription Factors/metabolism; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Humans; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction/physiology; Transcription Factors/genetics; Transcription Factors/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

Key words

Heat shock; Heat shock proteins (HSPs); hPDMCs (hPDMCs)

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Full text: 1 Database: MEDLINE Main subject: P38 Mitogen-Activated Protein Kinases / Hyperthermia, Induced Type of study: Prognostic_studies Language: En Journal: Stem Cell Res Ther Year: 2022 Type: Article Affiliation country: Taiwan

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