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Daisaikoto improves fatty liver and obesity in melanocortin-4 receptor gene-deficient mice via the activation of brown adipose tissue.
Morita, Shinichi; Sakamaki, Akira; Koyama, Kyutaro; Shibata, Osamu; Owaki, Takashi; Oda, Chiyumi; Kimura, Atsushi; Nakaya, Taiki; Ohbuchi, Katsuya; Nahata, Miwa; Fujitsuka, Naoki; Sakai, Norihiro; Abe, Hiroyuki; Kamimura, Kenya; Terai, Shuji.
Affiliation
  • Morita S; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Sakamaki A; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan. saka-a@med.niigata-u.ac.jp.
  • Koyama K; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Shibata O; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Owaki T; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Oda C; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Kimura A; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Nakaya T; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., 3586, Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan.
  • Ohbuchi K; Tsumura Advanced Technology Research Laboratories, Tsumura & Co., 3586, Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan.
  • Nahata M; Tsumura Kampo Research Laboratories, Tsumura & Co., 3586, Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan.
  • Fujitsuka N; Tsumura Kampo Research Laboratories, Tsumura & Co., 3586, Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki, 300-1192, Japan.
  • Sakai N; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Abe H; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Kamimura K; Division of Gastroenterology and Hepatology, Graduate School of Medical and Dental Sciences, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
  • Terai S; Department of General Medicine, School of Medicine, Niigata University, 1-757, Asahimachi-dori, Chuo-ku, Niigata, 951-8510, Japan.
Sci Rep ; 12(1): 10105, 2022 06 16.
Article in En | MEDLINE | ID: mdl-35710868
ABSTRACT
Melanocortin 4 receptor gene-knockout (MC4R-KO) mice are known to develop obesity with a high-fat diet. Meanwhile, daisaikoto, one of Kampo medicines, is a drug that is expected to have therapeutic effects on obesity. Here, we report the efficacy of daisaikoto in MC4R-KO mice. Eight-week-old MC4R-KO male mice (n = 12) were divided into three groups as follows the SD group, which is fed with a standard diet; the HFD group, fed a high-fat diet; and the DSK group, fed with a high-fat diet containing 10% of daisaikoto. After the four-week observation period, mice in each group were sacrificed and samples were collected. The body weights at 12 weeks were significantly higher in the HFD group than in the other groups, indicating that daisaikoto significantly reduced body weight gain and fat deposition of the liver. The metabolome analysis indicated that degradation of triglycerides and fatty acid oxidation in the liver were enhanced by daisaikoto administration. In MC4R-KO mice, the cytoplasm and uncoupling protein 1 expression of brown adipose tissue was decreased; however, it was reversed in the DSK group. In conclusion, daisaikoto has potentially improved fatty liver and obesity, making it a useful therapeutic agent for obesity and fatty liver.
Subject(s)

Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Adipose Tissue, Brown / Fatty Liver Language: En Journal: Sci Rep Year: 2022 Type: Article Affiliation country: Japan

Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Adipose Tissue, Brown / Fatty Liver Language: En Journal: Sci Rep Year: 2022 Type: Article Affiliation country: Japan