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Implantable Electronic Medicine Enabled by Bioresorbable Microneedles for Wireless Electrotherapy and Drug Delivery.
Huang, Ya; Li, Hu; Hu, Tianli; Li, Jian; Yiu, Chun Ki; Zhou, Jingkun; Li, Jiyu; Huang, Xingcan; Yao, Kuanming; Qiu, Xiao; Zhou, Yu; Li, Dengfeng; Zhang, Binbin; Shi, Rui; Liu, Yiming; Wong, Tsz Hung; Wu, Mengge; Jia, Huiling; Gao, Zhan; Zhang, Zhibiao; He, Jiahui; Zheng, Mengjia; Song, Enming; Wang, Lidai; Xu, Chenjie; Yu, Xinge.
Affiliation
  • Huang Y; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Li H; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Hu T; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Li J; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Yiu CK; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Zhou J; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Li J; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Huang X; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Yao K; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Qiu X; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Zhou Y; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Li D; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Zhang B; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Shi R; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Liu Y; Department of Electronic & Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, People's Republic of China.
  • Wong TH; Department of Electronic & Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong 999077, People's Republic of China.
  • Wu M; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Jia H; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • Gao Z; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Zhang Z; Hong Kong Centre for Cerebro-Cardiovascular Health Engineering, Hong Kong Science Park, New Territories, Hong Kong 999077, People's Republic of China.
  • He J; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Zheng M; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Song E; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Wang L; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Xu C; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
  • Yu X; Department of Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, People's Republic of China.
Nano Lett ; 22(14): 5944-5953, 2022 07 27.
Article in En | MEDLINE | ID: mdl-35816764
ABSTRACT
A combined treatment using medication and electrostimulation increases its effectiveness in comparison with one treatment alone. However, the organic integration of two strategies in one miniaturized system for practical usage has seldom been reported. This article reports an implantable electronic medicine based on bioresorbable microneedle devices that is activated wirelessly for electrostimulation and sustainable delivery of anti-inflammatory drugs. The electronic medicine is composed of a radio frequency wireless power transmission system and a drug-loaded microneedle structure, all fabricated with bioresorbable materials. In a rat skeletal muscle injury model, periodic electrostimulation regulates cell behaviors and tissue regeneration while the anti-inflammatory drugs prevent inflammation, which ultimately enhance the skeletal muscle regeneration. Finally, the electronic medicine is fully bioresorbable, excluding the second surgery for device removal.
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Full text: 1 Database: MEDLINE Main subject: Electric Stimulation Therapy / Absorbable Implants Language: En Journal: Nano Lett Year: 2022 Type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Database: MEDLINE Main subject: Electric Stimulation Therapy / Absorbable Implants Language: En Journal: Nano Lett Year: 2022 Type: Article