Fangchinoline abrogates growth and survival of hepatocellular carcinoma by negative regulation of c-met/HGF and its associated downstream signaling pathways.

Jung, Young Yun; Um, Jae-Young; Sethi, Gautam; Ahn, Kwang Seok

Jung, Young Yun; Um, Jae-Young; Sethi, Gautam; Ahn, Kwang Seok.

Affiliation

Jung YY; Department of Science in Korean Medicine, Kyung Hee University, Seoul, South Korea.
Um JY; Department of Science in Korean Medicine, Kyung Hee University, Seoul, South Korea.
Sethi G; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Ahn KS; Department of Science in Korean Medicine, Kyung Hee University, Seoul, South Korea.

Phytother Res ; 36(12): 4542-4557, 2022 Dec.

Article in En | MEDLINE | ID: mdl-35867025

Subject(s)

Benzylisoquinolines; Carcinoma, Hepatocellular; Liver Neoplasms; Animals; Humans; Mice; Carcinoma, Hepatocellular/drug therapy; Disease Models, Animal; Hepatocyte Growth Factor; Liver Neoplasms/drug therapy; Phosphatidylinositol 3-Kinases; Signal Transduction; Hep G2 Cells; Benzylisoquinolines/pharmacology

Key words

Fangchinoline; PI3K/AKT; apoptosis; c-met; hepatocellular carcinoma

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Full text: 1 Database: MEDLINE Main subject: Carcinoma, Hepatocellular / Benzylisoquinolines / Liver Neoplasms Type of study: Prognostic_studies / Risk_factors_studies Language: En Journal: Phytother Res Year: 2022 Type: Article Affiliation country: South Korea

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