Oxysophocarpine inhibits airway inflammation and mucus hypersecretion through JNK/AP-1 pathway in vivo and in vitro.

Zhi, Wenbing; Jiang, Shengnan; Xu, Zongren; An, Yuye; Chen, Jing; Li, Ye; Liu, Yang; Zhang, Hong

Zhi, Wenbing; Jiang, Shengnan; Xu, Zongren; An, Yuye; Chen, Jing; Li, Ye; Liu, Yang; Zhang, Hong.

Affiliation

Zhi W; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China.
Jiang S; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China.
Xu Z; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China.
An Y; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
Chen J; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
Li Y; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China.
Liu Y; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China. Electronic address: liuyang311111@163.com.
Zhang H; Shaanxi Academy of Traditional Chinese Medicine (Shaanxi Traditional Chinese Medicine Hospital), Xi'an 710003, PR China; Pharmacy College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, China. Electronic address: zhanghong919919@163.com.

Fitoterapia ; 162: 105278, 2022 Oct.

Article in En | MEDLINE | ID: mdl-35970410

Subject(s)

Alkaloids; Asthma; Quinolizidines; Alkaloids/metabolism; Alkaloids/pharmacology; Animals; Antioxidants/pharmacology; Asthma/drug therapy; Cytokines/metabolism; Disease Models, Animal; Eosine Yellowish-(YS)/metabolism; Eosine Yellowish-(YS)/pharmacology; Eosine Yellowish-(YS)/therapeutic use; Hematoxylin/metabolism; Hematoxylin/pharmacology; Hematoxylin/therapeutic use; Immunoglobulin E; Interleukin-4/metabolism; Interleukin-4/pharmacology; Interleukin-4/therapeutic use; Interleukin-5/metabolism; Interleukin-5/pharmacology; Interleukin-5/therapeutic use; Interleukin-6/metabolism; Interleukin-8/metabolism; JNK Mitogen-Activated Protein Kinases/metabolism; Lipopolysaccharides/pharmacology; Lung; Mice; Mice, Inbred BALB C; Molecular Structure; Mucins/metabolism; Mucins/pharmacology; Mucins/therapeutic use; Mucus/metabolism; Ovalbumin/metabolism; Periodic Acid/metabolism; Periodic Acid/pharmacology; Periodic Acid/therapeutic use; Quinolizidines/pharmacology; RNA, Messenger/metabolism; Tolonium Chloride/metabolism; Tolonium Chloride/pharmacology; Tolonium Chloride/therapeutic use; Transcription Factor AP-1/metabolism; Transcription Factor AP-1/pharmacology; Transcription Factor AP-1/therapeutic use

Key words

Airway inflammation; Asthma; JNK/AP-1 signaling pathway; Mucin; Oxysophocarpine

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google

Full text: 1 Database: MEDLINE Main subject: Asthma / Alkaloids / Quinolizidines Type of study: Prognostic_studies Language: En Journal: Fitoterapia Year: 2022 Type: Article

Fulltext

Add to My VHL

XML

PubMed Links

Search on Google