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Genetic polymorphisms of pharmacogenomic VIP variants in the Lahu population from Yunnan Province.
Dou, Xia; Yang, Shuangyu; Zhang, Wenjie; Meng, Wenting; Zhao, Weiwei; Hao, Jie; Hu, Xiuxia; Guo, Le; Jin, Tianbo.
Affiliation
  • Dou X; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Yang S; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Zhang W; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Meng W; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Zhao W; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Hao J; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Hu X; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Guo L; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
  • Jin T; College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Northwest University, Xi'an, Shaanxi 710069, China; Biomedicine Key Laboratory of Shaanxi Province, Northwest University, Xi'an 7
Gene ; 844: 146825, 2022 Nov 30.
Article in En | MEDLINE | ID: mdl-35995116
ABSTRACT

BACKGROUND:

Pharmacogenomics has been widely used to study the very important pharmacogenetic (VIP) variants among populations, but information on pharmacogenomics in the Lahu population is limited. The purpose of this study was to determine the differences in the distribution of VIP variants between the Lahu and the other 26 populations.

METHODS:

We genotyped 55 VIP variants of 27 genes in the Lahu population from the PharmGKB database. χ2 test was used to compare the genotype and allele frequencies between the Lahu and the other 26 populations from the 1000 Genomes Project.

RESULTS:

The genotype and allele frequencies of single nucleotide polymorphisms (SNPs) on rs20417 (PTGS2), rs776746 (CYP3A5), rs2115819 (ALOX5), and rs3093105 (CYP4F2) were considerably different in the Lahu population compared with those in the other 26 populations. Besides, based on the PharmGKB database, we identified several VIP variants that may alter the drug metabolism of aspirin (PTGS2), tacrolimus (CYP3A5), montelukast (ALOX5), and vitamin E (CYP4F2).

CONCLUSION:

The results show that there are significant differences in the genotype frequency distribution between the Lahu and the other 26 populations. Our study supplements the pharmacogenomics information of the Lahu population and provides a theoretical basis for individualized medicine in Lahu.
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Full text: 1 Database: MEDLINE Main subject: Pharmacogenetics / Cytochrome P-450 CYP3A Country/Region as subject: Asia Language: En Journal: Gene Year: 2022 Type: Article
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Database: MEDLINE Main subject: Pharmacogenetics / Cytochrome P-450 CYP3A Country/Region as subject: Asia Language: En Journal: Gene Year: 2022 Type: Article