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Short- and Long-Term Effects of Suboptimal Selenium Intake and Developmental Lead Exposure on Behavior and Hippocampal Glutamate Receptors in a Rat Model.
Tartaglione, Anna Maria; Serafini, Melania Maria; Ferraris, Francesca; Raggi, Andrea; Mirabello, Annalisa; Di Benedetto, Rita; Ricceri, Laura; Midali, Miriam; Cubadda, Francesco; Minghetti, Luisa; Viviani, Barbara; Calamandrei, Gemma.
Affiliation
  • Tartaglione AM; Centre for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Serafini MM; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20126 Milan, ML, Italy.
  • Ferraris F; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Raggi A; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Mirabello A; Centre for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Di Benedetto R; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Ricceri L; Centre for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Midali M; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20126 Milan, ML, Italy.
  • Cubadda F; Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Minghetti L; Research Coordination and Support Service, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
  • Viviani B; Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, 20126 Milan, ML, Italy.
  • Calamandrei G; Centre for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità (ISS), 00161 Rome, RM, Italy.
Nutrients ; 14(16)2022 Aug 10.
Article in En | MEDLINE | ID: mdl-36014775
Selenium (Se) is an essential trace element required for normal development as well as to counteract the adverse effects of environmental stressors. Conditions of low Se intake are present in some European countries. Our aim was to investigate the short- and long-term effects of early-life low Se supply on behavior and synaptic plasticity with a focus on the hippocampus, considering both suboptimal Se intake per se and its interaction with developmental exposure to lead (Pb). We established an animal model of Se restriction and low Pb exposure; female rats fed with an optimal (0.15 mg/kg) or suboptimal (0.04 mg/kg) Se diet were exposed from one month pre-mating until the end of lactation to 12.5 µg/mL Pb via drinking water. In rat offspring, the assessment of motor, emotional, and cognitive endpoints at different life stages were complemented by the evaluation of the expression and synaptic distribution of NMDA and AMPA receptor subunits at post-natal day (PND) 23 and 70 in the hippocampus. Suboptimal Se intake delayed the achievement of developmental milestones and induced early and long-term alterations in motor and emotional abilities. Behavioral alterations were mirrored by a drop in the expression of the majority of NMDA and AMPA receptor subunits analyzed at PND 23. The suboptimal Se status co-occurring with Pb exposure induced a transient body weight increase and persistent anxiety-like behavior. From the molecular point of view, we observed hippocampal alterations in NMDA (Glun2B and GluN1) and AMPA receptor subunit trafficking to the post-synapse in male rats only. Our study provides evidence of potential Se interactions with Pb in the developing brain.
Subject(s)
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Full text: 1 Database: MEDLINE Main subject: Selenium / Behavior, Animal / Developmental Disabilities / Receptors, Glutamate / Hippocampus / Lead Type of study: Etiology_studies Language: En Journal: Nutrients Year: 2022 Type: Article Affiliation country: Italy

Full text: 1 Database: MEDLINE Main subject: Selenium / Behavior, Animal / Developmental Disabilities / Receptors, Glutamate / Hippocampus / Lead Type of study: Etiology_studies Language: En Journal: Nutrients Year: 2022 Type: Article Affiliation country: Italy