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Role of solid lipid nanoparticle for the delivery of Lipophilic Drugs and Herbal Medicines in the treatment of pulmonary hypertension.
Bhatia, Tanuja; Gupta, G D; Kurmi, Balak Das; Singh, Dilpreet.
Affiliation
  • Bhatia T; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab (142001), India.
  • Gupta GD; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab (142001), India.
  • Kurmi BD; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab (142001), India.
  • Singh D; Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab (142001), India.
Pharm Nanotechnol ; 2022 Aug 31.
Article in En | MEDLINE | ID: mdl-36045536
ABSTRACT
Pulmonary arterial hypertension (PAH) is an uncommon condition marked by elevated pulmonary artery pressure that leads to right ventricular failure. The majority of drugs are now been approved by FDA for PAH, however, several biopharmaceutical hindrances lead to failure of the therapy. Various novel drug delivery systems are available in the literature from which lipid-based nanoparticles i.e. solid lipid nanoparticle is widely investigated for improving the solubility and bioavailability of drugs. In this paper, the prototype phytoconstituents used in pulmonary arterial hypertension have limited solubility and bioavailability. We highlighted the novel concepts of SLN for lipophilic phytoconstituents with their potential applications. This paper also reviews the present state of the art regarding production techniques for SLN like High-Pressure Homogenization, Micro-emulsion Technique, and Phase Inversion Temperature Method, etc. Furthermore, toxicity aspects and in vivo fate of SLN are also highlighted in this review. In a nutshell, safer delivery of phytoconstituents by SLN added a novel feather to the cap of successful drug delivery technologies.
Key words

Full text: 1 Database: MEDLINE Language: En Journal: Pharm Nanotechnol Year: 2022 Type: Article Affiliation country: India

Full text: 1 Database: MEDLINE Language: En Journal: Pharm Nanotechnol Year: 2022 Type: Article Affiliation country: India