23-O-acetylshengmanol-3-O-&#945;-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting I&#954;B/NF-&#954;B and MAPK/AP-1 signaling pathways.

Chen, Chunyan; Li, Lin; Liu, Xiaomei; Zhang, Deqin; Liu, Yang; Li, Yuhong

23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways.

Chen, Chunyan; Li, Lin; Liu, Xiaomei; Zhang, Deqin; Liu, Yang; Li, Yuhong.

Affiliation

Chen C; Key Laboratory of Traditional Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Li L; Key Laboratory of Traditional Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Liu X; Key Laboratory of Traditional Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Zhang D; Key Laboratory of Traditional Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Liu Y; College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Electronic address: yangliu@tjutcm.edu.cn.
Li Y; Key Laboratory of Traditional Chinese Medical Pharmacology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China; College of Traditional Chinese

J Ethnopharmacol ; 300: 115725, 2023 Jan 10.

Article in En | MEDLINE | ID: mdl-36115602

Subject(s)

Acute Lung Injury; Pulmonary Edema; Triterpenes; Acute Lung Injury/chemically induced; Acute Lung Injury/drug therapy; Animals; Anti-Inflammatory Agents; Caspases/metabolism; Cyclooxygenase 2/metabolism; Eosine Yellowish-(YS); Glycosides/pharmacology; Hematoxylin/pharmacology; Hematoxylin/therapeutic use; I-kappa B Proteins/metabolism; Inflammation Mediators/metabolism; Interleukin-6; Lipopolysaccharides/toxicity; Mice; Mitogen-Activated Protein Kinases/metabolism; NF-KappaB Inhibitor alpha/metabolism; NF-kappa B/metabolism; NLR Family, Pyrin Domain-Containing 3 Protein; Nitric Oxide/metabolism; RNA, Messenger; Signal Transduction; Transcription Factor AP-1/metabolism; Tumor Necrosis Factor-alpha/pharmacology

Key words

23-O-Acetylshengmanol-3-o-α-L-arabinoside; Acute lung injury; Anti-Inflammatory effects; IκBα/NF-κB; MAPKs/AP-1; Macrophages

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Full text: 1 Database: MEDLINE Traditional Medicines: Medicinas_tradicionales_de_asia / Medicina_china Main subject: Pulmonary Edema / Triterpenes / Acute Lung Injury Language: En Journal: J Ethnopharmacol Year: 2023 Type: Article Affiliation country: China

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