Two Novel Sesquiterpenoid Glycosides from the Rhizomes of Atractylodes lancea.
Molecules
; 27(18)2022 Sep 06.
Article
in En
| MEDLINE
| ID: mdl-36144486
ABSTRACT
Secoatractylohexone A (1), an unprecedented secoguaiane lactone glycoside featuring 6/7 cores and dihydroxy-9-guaine-3-one 11-O-ß-d-glucopyranoside (2), a 9,10-unsaturated guaiene-type glycoside possessing an uncommon scaffold, were isolated from the water-soluble portion of the ethanolic extract of Atractylodes lancea rhizomes together with five known compounds (3-7). The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data and application of the CD technique. The potential biological activities of secoatractylohexone A were predicted by network pharmacology in silico, the result of which indicated that secoatractylohexone A may be used to treat type II diabetes.
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Sesquiterpenes
/
Atractylodes
/
Diabetes Mellitus, Type 2
Language:
En
Journal:
Molecules
Year:
2022
Type:
Article
Affiliation country:
China