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Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation.
Lim, Ryan G; Al-Dalahmah, Osama; Wu, Jie; Gold, Maxwell P; Reidling, Jack C; Tang, Guomei; Adam, Miriam; Dansu, David K; Park, Hye-Jin; Casaccia, Patrizia; Miramontes, Ricardo; Reyes-Ortiz, Andrea M; Lau, Alice; Hickman, Richard A; Khan, Fatima; Paryani, Fahad; Tang, Alice; Ofori, Kenneth; Miyoshi, Emily; Michael, Neethu; McClure, Nicolette; Flowers, Xena E; Vonsattel, Jean Paul; Davidson, Shawn; Menon, Vilas; Swarup, Vivek; Fraenkel, Ernest; Goldman, James E; Thompson, Leslie M.
Affiliation
  • Lim RG; UCI MIND, University of California Irvine, Irvine, CA, USA.
  • Al-Dalahmah O; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Wu J; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
  • Gold MP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Reidling JC; UCI MIND, University of California Irvine, Irvine, CA, USA.
  • Tang G; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Adam M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Dansu DK; Advanced Science Research Center at the City University of New York, New York, NY, USA.
  • Park HJ; Advanced Science Research Center at the City University of New York, New York, NY, USA.
  • Casaccia P; Advanced Science Research Center at the City University of New York, New York, NY, USA.
  • Miramontes R; UCI MIND, University of California Irvine, Irvine, CA, USA.
  • Reyes-Ortiz AM; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA.
  • Lau A; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA, USA.
  • Hickman RA; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Khan F; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Paryani F; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Tang A; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Ofori K; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Miyoshi E; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
  • Michael N; Department of Pathology, University of California Irvine, Irvine, CA, USA.
  • McClure N; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
  • Flowers XE; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Vonsattel JP; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, NY, USA.
  • Davidson S; Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Menon V; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York City, New York, NY, USA.
  • Swarup V; Lewis-Sigler Institute for Integrative Genomics, Princeton, NJ, USA.
  • Fraenkel E; Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
  • Goldman JE; UCI MIND, University of California Irvine, Irvine, CA, USA.
  • Thompson LM; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.
Nat Commun ; 13(1): 7791, 2022 12 21.
Article in En | MEDLINE | ID: mdl-36543778
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Full text: 1 Database: MEDLINE Main subject: Thiamine / Biotin / Oligodendroglia / Huntington Disease Language: En Journal: Nat Commun Year: 2022 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Thiamine / Biotin / Oligodendroglia / Huntington Disease Language: En Journal: Nat Commun Year: 2022 Type: Article Affiliation country: United States