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Targeted photothermal release of antibiotics by a graphene nanoribbon-based supramolecular glycomaterial.
Shang, Ying; Zhang, Sheng; Gan, Hui-Qi; Yan, Kai-Cheng; Xu, Fugui; Mai, Yiyong; Chen, Daijie; Hu, Xi-Le; Zou, Lei; James, Tony D; He, Xiao-Peng.
Affiliation
  • Shang Y; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • Zhang S; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • Gan HQ; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • Yan KC; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • Xu F; Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk.
  • Mai Y; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, 800 Dongchuan RD. Minhang District, Shanghai 200240, China.
  • Chen D; School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, 800 Dongchuan RD. Minhang District, Shanghai 200240, China.
  • Hu XL; School of Pharmacy, Shanghai Jiao Tong University, 800 Dongchuan RD. Minhang District, Shanghai 200240, China.
  • Zou L; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • James TD; Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Sh
  • He XP; Department of Chemistry, University of Bath, Bath, BA2 7AY, UK. t.d.james@bath.ac.uk.
Chem Commun (Camb) ; 59(8): 1094-1097, 2023 Jan 24.
Article in En | MEDLINE | ID: mdl-36625183
ABSTRACT
Here, we report the simple construction of a supramolecular glycomaterial for the targeted delivery of antibiotics to P. aeruginosa in a photothermally-controlled manner. A galactose-pyrene conjugate (Gal-pyr) was developed to self-assemble with graphene nanoribbon-based nanowires via π-π stacking to produce a supramolecular glycomaterial, which exhibits a 1250-fold enhanced binding avidity toward a galactose-selective lectin when compared to Gal-pyr. The as-prepared glycomaterial when loaded with an antibiotic that acts as an inhibitor of the bacterial folic acid biosynthetic pathway eradicated P. aeruginosa-derived biofilms under near-infrared light irradiation due to the strong photothermal effect of the nanowires accelerating antibiotic release.
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Full text: 1 Database: MEDLINE Main subject: Nanotubes, Carbon / Graphite Language: En Journal: Chem Commun (Camb) Year: 2023 Type: Article
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Full text: 1 Database: MEDLINE Main subject: Nanotubes, Carbon / Graphite Language: En Journal: Chem Commun (Camb) Year: 2023 Type: Article