Trait- and State-Dependent Changes in Cortical-Subcortical Functional Networks Across the Adult Lifespan.
J Magn Reson Imaging
; 58(3): 720-731, 2023 09.
Article
in En
| MEDLINE
| ID: mdl-36637029
ABSTRACT
BACKGROUND:
How the functional interactions of the basal ganglia/thalamus with the cerebral cortex and the cerebellum change over the adult lifespan in movie-watching and resting-state is less clear.PURPOSE:
To investigate the functional changes in the organization of the human cortical-subcortical functional networks over the adult lifespan using movie-watching and resting-state fMRI data. STUDY TYPE Cohort.SUBJECTS:
Healthy 467 adults (cross-sectional individuals aged 18-88 years) from the Cambridge Centre for Ageing and Neuroscience (www.cam-can.com). FIELD STRENGTH/SEQUENCE fMRI using a gradient-echo echo-planar imaging (EPI) sequence at 3 T. ASSESSMENT Functional connectivities (FCs) of the subcortical subregions (i.e. the basal ganglia and thalamus) with both the cerebral cortex and cerebellum were examined in fMRI data acquired during resting state and movie-watching. And, fluid intelligence scores were also assessed. STATISTICAL TESTS Student's t-tests, false discovery rate (FDR) corrected.RESULTS:
As age increased, FCs that mainly within the basal ganglia and thalamus, and between the basal ganglia/thalamus and cortical networks (including the dorsal attention, ventral attention, and limbic networks) were both increased/decreased during movie-watching and resting states. However, FCs showed a state-dependent component with advancing age. During the movie-watching state, the FCs between the basal ganglia/thalamus and cerebellum/frontoparietal control networks were mainly increased with age, and the FCs in the somatomotor network were decreased with age. During the resting state, the FCs between the basal ganglia/thalamus and default mode/visual networks were mainly increased with age, and the FCs in the cerebellum were mainly decreased with age. Moreover, inverse relationships between FCs and fluid intelligence were mainly found in these network regions. DATACONCLUSION:
Our study may suggest that changes in cortical-subcortical functional networks across the adult lifespan were both state-dependent and stable traits, and that aging fMRI studies should consider the effects of both physiological characteristics and individual situations. EVIDENCE LEVEL 2. TECHNICAL EFFICACY Stage 3.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Basal Ganglia
/
Longevity
Type of study:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Language:
En
Journal:
J Magn Reson Imaging
Year:
2023
Type:
Article
Affiliation country:
China