Mitochondrial dysfunction in a rat model and the related risk of metabolic disorders.
J Tradit Chin Med
; 43(1): 95-104, 2023 02.
Article
in En
| MEDLINE
| ID: mdl-36640000
ABSTRACT
OBJECTIVE:
To explore whether kidney deficiency (KYD) is prone to metabolic disorders may be linked to impaired mitochondrial function in thermogenesis and metabolic tissues.METHODS:
A rat model of KYD was used, which was established using Sprague Dawley rat dams with warm preference subjected to herbal treatment that can improve kidney . The human relevance was confirmed by reduced serum corticosterone levels, and increased preference for warm location.RESULTS:
KYD Rats were underdeveloped. Adenosine-triphosphate (ATP) production was reduced in the brown fat, but increased in the muscle. However, oxidative phosphorylated complexes to generate ATP and mitochondrial biogenesis marker were reduced in both tissues. When the second insult of high-fat diet (HFD) was introduced, KYD rats gained less weight yet developed more severe lipid and glucose metabolic disorders. This may be driven by disregulated liver gluconeogenesis marker forkhead box protein O1 and lipid metabolic regulator cholesterol 7 alpha-hydroxylase.CONCLUSION:
KYD rats exhibited reduced mito-chondrial function in the brown fat, but were partially compensated by skeletal muscle, associated with the phenotype of warm preference and metabolic disorder, which was further exacerbated by additional HFD consumption. Future studies can focus on treatment targetting mitochondria function to reverse this phenotype.Key words
Full text:
1
Database:
MEDLINE
Main subject:
Metabolic Diseases
/
Mitochondria
Type of study:
Etiology_studies
/
Risk_factors_studies
Language:
En
Journal:
J Tradit Chin Med
Year:
2023
Type:
Article
Affiliation country:
China