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Inhibition of Soluble Stem Cell Factor Promotes Intestinal Mucosal Repair.
Garcia-Hernandez, Vicky; Raya-Sandino, Arturo; Azcutia, Veronica; Miranda, Jael; Kelm, Matthias; Flemming, Sven; Birkl, Dorothee; Quiros, Miguel; Brazil, Jennifer C; Parkos, Charles A; Nusrat, Asma.
Affiliation
  • Garcia-Hernandez V; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Raya-Sandino A; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Azcutia V; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Miranda J; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Kelm M; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Flemming S; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Birkl D; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Quiros M; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Brazil JC; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Parkos CA; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
  • Nusrat A; Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA.
Inflamm Bowel Dis ; 29(7): 1133-1144, 2023 07 05.
Article in En | MEDLINE | ID: mdl-36688460
Our investigation demonstrates that blocking cleavable SCF248 isoform by administration of specific stem cell factor antibodies enhances healing of the intestinal mucosa and restores critical barrier function, suggesting an alternative therapeutic option to treat individuals with active IBD.
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Full text: 1 Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Colitis Type of study: Prognostic_studies Language: En Journal: Inflamm Bowel Dis Year: 2023 Type: Article Affiliation country: United States
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Full text: 1 Database: MEDLINE Main subject: Inflammatory Bowel Diseases / Colitis, Ulcerative / Colitis Type of study: Prognostic_studies Language: En Journal: Inflamm Bowel Dis Year: 2023 Type: Article Affiliation country: United States