Toll-like receptor 4 is a key regulator of asthma exacerbation caused by aluminum oxide nanoparticles via regulation of NF-&#954;B phosphorylation.

Lim, Je-Oh; Kim, Woong-Il; Pak, So-Won; Lee, Se-Jin; Park, Sung-Hyeuk; Shin, In-Sik; Kim, Jong-Choon

Toll-like receptor 4 is a key regulator of asthma exacerbation caused by aluminum oxide nanoparticles via regulation of NF-κB phosphorylation.

Lim, Je-Oh; Kim, Woong-Il; Pak, So-Won; Lee, Se-Jin; Park, Sung-Hyeuk; Shin, In-Sik; Kim, Jong-Choon.

Affiliation

Lim JO; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea; Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine, Naju 58245, Republic of Korea.
Kim WI; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Pak SW; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Lee SJ; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Park SH; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Shin IS; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea.
Kim JC; College of Veterinary Medicine and BK21 FOUR Program, Chonnam National University, Gwangju 61186, Republic of Korea. Electronic address: toxkim@jnu.ac.kr.

J Hazard Mater ; 448: 130884, 2023 04 15.

Article in En | MEDLINE | ID: mdl-36736217

Subject(s)

Asthma; NF-kappa B; Toll-Like Receptor 4; Animals; Humans; Mice; Asthma/chemically induced; Asthma/metabolism; Bronchoalveolar Lavage Fluid; Cytokines/metabolism; Lung; Mice, Inbred BALB C; Myeloid Differentiation Factor 88/genetics; Myeloid Differentiation Factor 88/metabolism; NF-kappa B/metabolism; NF-KappaB Inhibitor alpha/metabolism; NF-KappaB Inhibitor alpha/pharmacology; Ovalbumin; Phosphorylation; Toll-Like Receptor 4/genetics; Toll-Like Receptor 4/metabolism; Aluminum Oxide/adverse effects; Metal Nanoparticles/adverse effects

Key words

Airway inflammation; Aluminum oxide nanoparticle; Asthma; Nuclear factor-kappa B; Toll-like receptor 4

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Full text: 1 Database: MEDLINE Main subject: Asthma / NF-kappa B / Toll-Like Receptor 4 Language: En Journal: J Hazard Mater Year: 2023 Type: Article

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Full text: 1 Database: MEDLINE Main subject: Asthma / NF-kappa B / Toll-Like Receptor 4 Language: En Journal: J Hazard Mater Year: 2023 Type: Article