Preclinical study of experimental burns treated with photobiomodulation and Human Amniotic Membrane, both isolated and associated.
Rev Lat Am Enfermagem
; 31: e3726, 2023.
Article
in En, Pt, Es
| MEDLINE
| ID: mdl-36888787
ABSTRACT
OBJECTIVE:
to evaluate the effect of photobiomodulation with low-level 660 nm laser alone or associated with Human Amniotic Membrane in the repair of partial-thickness burns in rats.METHOD:
an experimental study conducted with 48 male Wistar rats, randomized into four groups Control, Human Amniotic Membrane, Low-Level Laser Therapy, and Low-Level Laser Therapy associated with Human Amniotic Membrane. The histopathological characteristics of the skin samples were analyzed 7 and 14 days after the burn. The data obtained were submitted to the Kolmogorov-Smirnov and Mann-Whitney tests.RESULTS:
the histological analysis of the burn injuries showed a decrease in inflammation (p<0.0001) and an increase in proliferation of fibroblasts (p<0.0001) mainly at 7 days in all treatments related to the control group. At 14 days, the greater effectiveness in accelerating the healing process was significant (p<0.0001) in the Low-Level Laser Therapy group associated with the Human Amniotic Membrane.CONCLUSION:
the association of photobiomodulation therapies with the Human Amniotic Membrane allowed verifying a reduction in the healing process time of the experimental lesions, stimulating its proposal as a treatment protocol in partial-thickness burns.
Full text:
1
Database:
MEDLINE
Therapeutic Methods and Therapies TCIM:
Terapias_energeticas
Main subject:
Burns
/
Low-Level Light Therapy
Type of study:
Clinical_trials
/
Guideline
/
Risk_factors_studies
Language:
En
/
Es
/
Pt
Journal:
Rev Lat Am Enfermagem
Year:
2023
Type:
Article
Affiliation country:
Brazil