Mechanism and Molecular Targets of a Water-Soluble Extract of <i>Artemisia annua</i> on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation.

Zhou, Wen-Shu; Silva, Marta; Yang, Chao; Li, Shuai; Chen, Yi-Tian; Zheng, Wen-Hua

Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation.

Zhou, Wen-Shu; Silva, Marta; Yang, Chao; Li, Shuai; Chen, Yi-Tian; Zheng, Wen-Hua.

Affiliation

Zhou WS; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.
Silva M; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.
Yang C; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.
Li S; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.
Chen YT; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.
Zheng WH; Center of Reproduction, Development & Aging and Institute of Translation Medicine, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, P. R. China.

Am J Chin Med ; 51(3): 595-622, 2023.

Article in En | MEDLINE | ID: mdl-36999542

Subject(s)

Alzheimer Disease; Artemisia annua; Mice; Animals; Alzheimer Disease/drug therapy; Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Artemisia annua/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Network Pharmacology; Antioxidants/pharmacology; Phosphatidylinositol 3-Kinases; Hydrogen Peroxide; bcl-2-Associated X Protein; Mice, Transgenic

Key words

Alzheimer's Disease; Artemisia annua; Network Pharmacology; Neuroprotective Effect; PI3K-AKT Signaling Pathway

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Terapias_biologicas / Aromoterapia Main subject: Artemisia annua / Alzheimer Disease Language: En Journal: Am J Chin Med Year: 2023 Type: Article

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