Integrated computational approach identifies potential inhibitors of ASK1-(JNK/P38) interaction signaling: new insights into cancer therapeutics.

Ogbodo, Uchechukwu C; Balogun, Toheeb A; Omoboyede, Victor

Ogbodo, Uchechukwu C; Balogun, Toheeb A; Omoboyede, Victor.

Affiliation

Ogbodo UC; Department of Applied Biochemistry, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Nigeria.
Balogun TA; Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Nigeria.
Omoboyede V; Department of Biochemistry, School of Life Sciences (SLS), Federal University of Technology Akure, Akure, Ondo State, Nigeria.

J Biomol Struct Dyn ; 42(2): 696-709, 2024.

Article in En | MEDLINE | ID: mdl-37021478

Subject(s)

MAP Kinase Kinase Kinase 5; Neoplasms; Humans; MAP Kinase Kinase Kinase 5/metabolism; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism; Molecular Docking Simulation; Signal Transduction; Neoplasms/drug therapy; Apoptosis/physiology

Key words

Cancer therapy; MMGBSA; apoptosis signal-regulating kinase 1; molecular docking; molecular dynamics

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Full text: 1 Database: MEDLINE Main subject: MAP Kinase Kinase Kinase 5 / Neoplasms Language: En Journal: J Biomol Struct Dyn Year: 2024 Type: Article Affiliation country: Nigeria

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