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Sensory gating functions of the auditory thalamus: Adaptation and modulations through noise-exposure and high-frequency stimulation in rats.
Zare, Aryo; van Zwieten, Gusta; Kotz, Sonja A; Temel, Yasin; Almasabi, Faris; Schultz, Benjamin G; Schwartze, Michael; Janssen, Marcus L F.
Affiliation
  • Zare A; School for Mental Health and Neuroscience, Faculty of Health Medicine, and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.
  • van Zwieten G; School for Mental Health and Neuroscience, Faculty of Health Medicine, and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Ear, Nose and Throat/Head and Neck Surgery, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Kotz SA; Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
  • Temel Y; School for Mental Health and Neuroscience, Faculty of Health Medicine, and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Neurosurgery, Maastricht University Medical Center, Maastricht, the Netherlands.
  • Almasabi F; School for Mental Health and Neuroscience, Faculty of Health Medicine, and Life Sciences, Maastricht University, Maastricht, the Netherlands; Physiology Department, Faculty of Medicine, King Khalid University, Abha, Saudi Arabia.
  • Schultz BG; Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands.
  • Schwartze M; Department of Neuropsychology and Psychopharmacology, Maastricht University, the Netherlands. Electronic address: michael.schwartze@maastrichtuniversity.nl.
  • Janssen MLF; School for Mental Health and Neuroscience, Faculty of Health Medicine, and Life Sciences, Maastricht University, Maastricht, the Netherlands; Department of Clinical Neurophysiology, Maastricht University Medical Center, Maastricht, the Netherlands. Electronic address: m.janssen@maastrichtuniversity.
Behav Brain Res ; 450: 114498, 2023 07 26.
Article in En | MEDLINE | ID: mdl-37201892
The medial geniculate body (MGB) of the thalamus is an obligatory relay for auditory processing. A breakdown of adaptive filtering and sensory gating at this level may lead to multiple auditory dysfunctions, while high-frequency stimulation (HFS) of the MGB might mitigate aberrant sensory gating. To further investigate the sensory gating functions of the MGB, this study (i) recorded electrophysiological evoked potentials in response to continuous auditory stimulation, and (ii) assessed the effect of MGB HFS on these responses in noise-exposed and control animals. Pure-tone sequences were presented to assess differential sensory gating functions associated with stimulus pitch, grouping (pairing), and temporal regularity. Evoked potentials were recorded from the MGB and acquired before and after HFS (100 Hz). All animals (unexposed and noise-exposed, pre- and post-HFS) showed gating for pitch and grouping. Unexposed animals also showed gating for temporal regularity not found in noise-exposed animals. Moreover, only noise-exposed animals showed restoration comparable to the typical EP amplitude suppression following MGB HFS. The current findings confirm adaptive thalamic sensory gating based on different sound characteristics and provide evidence that temporal regularity affects MGB auditory signaling.
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Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Auditory Cortex / Thalamus Language: En Journal: Behav Brain Res Year: 2023 Type: Article Affiliation country: Netherlands

Full text: 1 Database: MEDLINE Complementary Medicines: Homeopatia Main subject: Auditory Cortex / Thalamus Language: En Journal: Behav Brain Res Year: 2023 Type: Article Affiliation country: Netherlands