Therapeutic effect of the total saponin from Panax Japonicus on experimental autoimmune encephalomyelitis by attenuating inflammation and regulating gut microbiota in mice.

Wang, Jing; He, Liying; Wang, Siyuan; Zhao, Hui; Chen, Jie; Dong, Yixin; Yasen, Subinuer; Wang, Lei; Zou, Haiyan

Wang, Jing; He, Liying; Wang, Siyuan; Zhao, Hui; Chen, Jie; Dong, Yixin; Yasen, Subinuer; Wang, Lei; Zou, Haiyan.

Affiliation

Wang J; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
He L; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China.
Wang S; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: wsy1698@foxmail.com.
Zhao H; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: zhaohuishouyi@ccmu.edu.cn.
Chen J; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: chenjie9922@163.com.
Dong Y; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: 2414319889@qq.com.
Yasen S; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: 15510170815@163.com.
Wang L; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: tmwangl@ccmu.edu.cn.
Zou H; School of Traditional Chinese Medicine, Capital Medical University, Beijing, 100069, China. Electronic address: zouhy@ccmu.edu.cn.

J Ethnopharmacol ; 315: 116681, 2023 Oct 28.

Article in En | MEDLINE | ID: mdl-37230280

Subject(s)

Encephalomyelitis, Autoimmune, Experimental; Gastrointestinal Microbiome; Mice; Animals; Encephalomyelitis, Autoimmune, Experimental/drug therapy; Encephalomyelitis, Autoimmune, Experimental/metabolism; Interleukin-17/metabolism; Tumor Necrosis Factor-alpha/metabolism; Interleukin-6/metabolism; NF-kappa B/metabolism; Lipopolysaccharides; Myeloid Differentiation Factor 88/metabolism; Toll-Like Receptor 4/metabolism; Cytokines/metabolism; Inflammation/pathology; Myelin-Oligodendrocyte Glycoprotein/metabolism; Myelin-Oligodendrocyte Glycoprotein/therapeutic use; Forkhead Transcription Factors/metabolism; RNA, Messenger; Mice, Inbred C57BL

Key words

Experimental autoimmune encephalomyelitis; Gut microbiota; Multiple sclerosis; Neuroinflammation; Panax japonicus; Saponins

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Full text: 1 Database: MEDLINE Therapeutic Methods and Therapies TCIM: Plantas_medicinales Main subject: Encephalomyelitis, Autoimmune, Experimental / Gastrointestinal Microbiome Type of study: Prognostic_studies Language: En Journal: J Ethnopharmacol Year: 2023 Type: Article Affiliation country: China

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