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Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses.
Xiong, Zheyu; Liu, Linhu; Jian, Zhongyu; Ma, Yucheng; Li, Hong; Jin, Xi; Liao, Banghua; Wang, Kunjie.
Affiliation
  • Xiong Z; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Liu L; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Jian Z; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Ma Y; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Li H; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Jin X; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Liao B; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
  • Wang K; Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China.
Nutrients ; 15(15)2023 Jul 25.
Article in En | MEDLINE | ID: mdl-37571239
The relationship between vitamin E intake or circulating α-tocopherol and various health outcomes is still debatable and uncertain. We conducted an umbrella review to identify the relationships between vitamin E intake or circulating tocopherol and health outcomes by merging and recalculating earlier meta-analyses. The connections that were found to be statistically significant were then classified into different evidence levels based on p values, between-study heterogeneity, prediction intervals, and small study effects. We finally included 32 eligible meta-analyses with four vitamin E sources and 64 unique health outcomes. Only the association between circulating α-tocopherol and wheeze or asthma in children was substantiated by consistent evidence. Suggestive evidence was suggested for seven results on endothelial function (supplemental vitamin E): serum C-reactive protein (CRP) concentrations (supplemental vitamin E), cervical cancer (dietary vitamin E), esophageal cancer (dietary vitamin E), cervical intraepithelial neoplasia (CIN, dietary vitamin E), pancreatic cancer (total vitamin E intake), and colorectal cancer (circulating α-tocopherol levels); all of these showed a protective effect consistent with the vitamin E source. In conclusion, our work has indicated that vitamin E is protective for several particular health outcomes. Further prospective studies are required when other factors that may contribute to bias are considered.
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Full text: 1 Database: MEDLINE Main subject: Vitamin E / Alpha-Tocopherol Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Language: En Journal: Nutrients Year: 2023 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Vitamin E / Alpha-Tocopherol Type of study: Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Language: En Journal: Nutrients Year: 2023 Type: Article Affiliation country: China