Monoterpene indole alkaloids from the roots of Alstonia rupestris and their anti-inflammatory activity.
Fitoterapia
; 171: 105689, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-37757920
ABSTRACT
Four new monoterpene indole alkaloids (1-4) together with twelve known alkaloids (5-16) were isolated from the roots of Alstonia rupestris. Compound 1 was the first example of C2-symmetric heteroyohimbine-type indole alkaloid homodimer obtained from natural plant resource. Their structures were elucidated on the basis of spectroscopic data. The absolute configuration of 1 was determined by comparison of its calculated and experimental electronic circular dichroism (ECD) spectra. All compounds were evaluated for their anti-inflammatory activities by measuring their NO inhibitory effects in LPS-stimulated RAW 264.7 cells. Compound 2 showed strong NO inhibition with IC50 value of 4.2 ± 1.3 µM. Moreover, compound 2 could decrease the expressions of cyclooxygenase-2 (COX-2) and transforming growth factor beta-1 (TGF-ß1).
Key words
Full text:
1
Database:
MEDLINE
Main subject:
Alstonia
Language:
En
Journal:
Fitoterapia
Year:
2023
Type:
Article