Interleukin-1ß triggers muscle-derived extracellular superoxide dismutase expression and protects muscles from doxorubicin-induced atrophy.

Yamada, Mami; Okutsu, Mitsuharu

Yamada, Mami; Okutsu, Mitsuharu.

Affiliation

Yamada M; Graduate School of Science, Nagoya City University, Nagoya Aichi, Japan.
Okutsu M; Graduate School of Science, Nagoya City University, Nagoya Aichi, Japan.

J Physiol ; 601(21): 4699-4721, 2023 11.

Article in En | MEDLINE | ID: mdl-37815420

Subject(s)

Antioxidants; Neoplasms; Humans; Mice; Animals; Antioxidants/pharmacology; Interleukin-1beta/metabolism; Interleukin-1beta/pharmacology; Interleukin-1beta/therapeutic use; Muscle, Skeletal/metabolism; Muscle Fibers, Skeletal/metabolism; Muscular Atrophy/chemically induced; Muscular Atrophy/prevention & control; Doxorubicin/toxicity; Doxorubicin/metabolism; Neoplasms/metabolism; Superoxide Dismutase/genetics; Superoxide Dismutase/metabolism; Recombinant Proteins/metabolism; Recombinant Proteins/pharmacology; Recombinant Proteins/therapeutic use

Key words

cell culture; doxorubicin; extracellular superoxide dismutase; interleukin-1ß; mouse skeletal muscle; muscle atrophy; oxidative stress

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Full text: 1 Database: MEDLINE Main subject: Neoplasms / Antioxidants Language: En Journal: J Physiol Year: 2023 Type: Article Affiliation country: Japan

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Full text: 1 Database: MEDLINE Main subject: Neoplasms / Antioxidants Language: En Journal: J Physiol Year: 2023 Type: Article Affiliation country: Japan