Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity.

Zhang, Dong-Li; Wang, Yue; Liu, Jing-Bo; Chen, Qian; Li, Shao-Yong; Jin, De-Jun; Tang, Sheng-An

Zhang, Dong-Li; Wang, Yue; Liu, Jing-Bo; Chen, Qian; Li, Shao-Yong; Jin, De-Jun; Tang, Sheng-An.

Affiliation

Zhang DL; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Wang Y; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Liu JB; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Chen Q; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Li SY; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Jin DJ; School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, PR China. Electronic address: 149119751@qq.com.
Tang SA; Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China. Electronic address: tangshengan@tmu.edu.cn.

Phytochemistry ; 217: 113900, 2024 Jan.

Article in En | MEDLINE | ID: mdl-37898415

ABSTRACT

ABSTRACT

A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1-5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC50 value of 2.09 µM.

Subject(s)

Triterpenes; Animals; Mice; Triterpenes/pharmacology; Triterpenes/chemistry; Macrophages; Plant Extracts/chemistry; Magnetic Resonance Spectroscopy; Anti-Inflammatory Agents/pharmacology; Anti-Inflammatory Agents/chemistry; Molecular Structure

Key words

Dichapetalaceae; Dichapetalin-type triterpenoid; Dichapetalum longipetalum; RAW264.7 murine macrophages

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