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Possible role of pomegranate fruit in reversing renal damage in rats exposed to Phenylhydrazine.
Soliman, Nabil Abbas; Mansour, Sherif Wajih; Ammar, Mohamed Ahmed; Hassan, Noura Ahmed; Mohamed, Rehab Hamed Abdallah.
Affiliation
  • Soliman NA; Department of Zoology, Faculty of Science, Zagazig University, Sharkia, Egypt.
  • Mansour SW; Department of Physiology, Faculty of medicine, Zagazig University, Sharkia, Egypt.
  • Ammar MA; Department of Zoology, Faculty of Science, Zawia University, Al Zawia City, Libya.
  • Hassan NA; Department of Pharmacology, Faculty of Pharmacy, Zagazig University, Sharkia, Egypt.
  • Mohamed RHA; Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Sharkia, Egypt.
Open Vet J ; 13(10): 1268-1276, 2023 Oct.
Article in En | MEDLINE | ID: mdl-38027401
Background: Pomegranate granatum (molasses and peels) and its constituents showed protective effects against natural toxins such as phenylhydrazine (PHZ) as well as chemical toxicants such as arsenic, diazinon, and carbon tetrachloride. Aim: The current study aimed to assess the effect of pomegranate molasses (PM), white peel extract, and red peel extract on nephrotoxicity induced by PHZ. Methods: 80 male rats were divided into eight equal groups; a control group, PM pure group, white peel pomegranate pure group, red peel pomegranate pure group, PHZ group, PM + PHZ group, white peel pomegranate + PHZ group and red peel pomegranate + PHZ group. Kidney function, inflammation markers, antioxidant activities, and renal tissue histopathology were investigated. Results: The results revealed that PHZ group showed a significant increase in lactate Dehydrogenase (LDH), malondialdehyde (MDA), creatinine, uric acid, BUNBUN, C - reactive protein (CRP), tumor necrosis factor, thiobarbituric acid reactive substances (TBARSs), and total antioxidant capacity (TAC) with a significant decrease of catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD) as compared with a control group. Other pomegranate-treated and PHZ co-treated groups with pomegranate showed a significant decrease of LDH, MDA, creatinine, uric acid, BUN, tumor necrosis factor, TBARSs, and TAC with a significant increase of CAT, GPx, and SOD as compared with PHZ group. Conclusion: Collectively, our data suggest that red, white peels, and molasses have anti-toxic and anti-inflammatory effects on renal function and tissues.
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Full text: 1 Database: MEDLINE Main subject: Pomegranate / Antioxidants Language: En Journal: Open Vet J Year: 2023 Type: Article Affiliation country: Egypt

Full text: 1 Database: MEDLINE Main subject: Pomegranate / Antioxidants Language: En Journal: Open Vet J Year: 2023 Type: Article Affiliation country: Egypt