Sex and interspecies differences in ESR2-expressing cell distributions in mouse and rat brains.
Biol Sex Differ
; 14(1): 89, 2023 12 18.
Article
in En
| MEDLINE
| ID: mdl-38111056
Although the brain is a major target organ of estrogens, the distribution of estrogen receptors in the brain is not fully understood. ESR2, also known as estrogen receptor ß, is an estrogen receptor subtype; its localization in the brain has long been controversial because it has traditionally been difficult to detect. In the present study, we analyzed the expression sites of ESR2 in mouse and rat brains using immunohistochemistry with a well-validated antibody, PPZ0506. The immunohistochemical analysis revealed a more localized expression of ESR2 protein in brain subregions than has previously been reported. Additionally, there were clear sex and interspecies differences in the distribution of this protein. We also observed changes in ESR2 expression in the female brain in response to circulating estrogen levels. Our results, which show the precise expression profiles of ESR2 protein in rodent brains, will be helpful for understanding the ESR2-mediated actions of estrogen.
Key words
Full text:
1
Database:
MEDLINE
Complementary Medicines:
Homeopatia
Main subject:
Brain
/
Receptors, Estrogen
/
Estrogen Receptor beta
Language:
En
Journal:
Biol Sex Differ
Year:
2023
Type:
Article
Affiliation country:
Japan