Alnustone: A review of its sources, pharmacology, and pharmacokinetics .
Curr Mol Pharmacol
; 2024 Jan 26.
Article
in En
| MEDLINE
| ID: mdl-38284732
ABSTRACT
Alnustone (4(E)-,6(E)-1,7-Diphenyl-hepta-4,6-dien-3-one) is a non-phenolic natural diarylheptanoid, which was first isolated and identified from the male flower of Alnus pendula (Betulaceae). It can also be isolated from Curcuma xanthorrhiza Roxb (Zingiberaceae) rhizomes and Alpinia katsumadai Hayata (Zingiberaceae) seeds. It was first synthesized through a five-step process from ß-phenyl propionyl chloride. In later years, new methods for synthesizing Alnustone were designed and performed with different yields. Due to the various therapeutic effects exhibited by alnustone like other diarylheptanoids, its biological activities such as antioxidant, antibacterial, and anti-inflammatory properties have been the subject of many studies. This article has reviewed different aspects of this valuable natural compound, including its natural and synthetic sources, therapeutic effects, and pharmacokinetics as a potential future therapeutic agent.
Full text:
1
Database:
MEDLINE
Language:
En
Journal:
Curr Mol Pharmacol
Year:
2024
Type:
Article
Affiliation country:
Iran