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Hesperidin Protects Against High-Fat Diet-Induced Lipotoxicity in Rats by Inhibiting Pyroptosis.
Luo, Ruixi; Hu, Yudie; Wang, La; Wang, Wenjia; Wang, Ping; Ke, Zunli; Lou, Didong; Tian, Weiyi.
Affiliation
  • Luo R; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Hu Y; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Wang; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Wang W; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Wang P; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Ke Z; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Lou D; Department of Forensic Medicine, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
  • Tian W; Department of Immunology and Microbiology, School of Basic Medical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
J Med Food ; 27(2): 154-166, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38294790
ABSTRACT
It is currently thought that excess fatty acid-induced lipotoxicity in hepatocytes is a critical initiator in the development of nonalcoholic fatty liver disease (NAFLD). Lipotoxicity can induce hepatocyte death; thus, reducing lipotoxicity is one of the most effective therapeutic methods to combat NAFLD. Abundant evidence has shown that hesperidin (HSP), a type of flavanone mainly found in citrus fruits, is able to ameliorate NAFLD, but the molecular mechanisms are unclear. We previously reported that pyroptosis contributed to NAFLD development and that inhibiting pyroptosis contributed to blunting the progression of NAFLD in rat models. Therefore, we questioned whether HSP could contribute to ameliorating NAFLD by modulating pyroptosis. In this study, a high-fat diet (HFD) induced dyslipidemia and hepatic lipotoxicity in rats, and HSP supplementation ameliorated dyslipidemia and insulin resistance. In addition, the HFD also caused pyroptosis in the liver and pancreas, while HSP supplementation ameliorated pyroptosis. In vitro, we found that HSP ameliorated palmitic acid-induced lipotoxicity and pyroptosis in HepG2 and INS-1E cells. In conclusion, we showed for the first time that HSP has a protective effect against liver and pancreas damage in terms of pyroptosis and provides a novel mechanism for the protective effects of HSP on NAFLD.
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Full text: 1 Database: MEDLINE Main subject: Dyslipidemias / Non-alcoholic Fatty Liver Disease / Hesperidin Language: En Journal: J Med Food Year: 2024 Type: Article Affiliation country: China

Full text: 1 Database: MEDLINE Main subject: Dyslipidemias / Non-alcoholic Fatty Liver Disease / Hesperidin Language: En Journal: J Med Food Year: 2024 Type: Article Affiliation country: China